Pharmacologically Induced Resistance to Heat Shock
نویسندگان
چکیده
منابع مشابه
Heat shock protein 70 is able to prevent heat shock-induced resistance of target cells to CTL.
Heat shock or transfection with heat shock protein 70 (Hsp70) genes has been shown to protect tumor cell lines against immune mechanisms of cytotoxicity. We have reported previously that heat shock confers resistance to CTL in the rat myeloma cell line Y3 that is Hsp70 defective. Evidence is now presented that Hsp70 is able to prevent the induction of the resistant phenotype. In Con A-stimulate...
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Acute heat shock initiates the phenomenon of “prompt” glycosylation, which is characterized by selective glycosylation of specific cellular proteins called the prompt stress glycoproteins (P-SG). Prompt glycosylation rapidly occurs even during short heating periods, e.g. 10 min at 45 “C, and is not affected by the presence of cycloheximide (Henle, K. J., Kaushal, G. P., Nagle, W. A, and Nolen, ...
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The screening of two different retroviral cDNA expression libraries to select genes that confer constitutive doxorubicin resistance has in both cases resulted in the isolation of the heat shock factor 1 (HSF1) transcription factor. We show that HSF1 induces a multidrug resistance phenotype that occurs in the absence of heat shock or cellular stress and is mediated at least in part through the c...
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ژورنال
عنوان ژورنال: Poultry Science
سال: 1960
ISSN: 0032-5791
DOI: 10.3382/ps.0390477